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CLINICAL REFERENCES

References are provided for educational purposes and relate to individual ingredients used in Alpha Shakes™.

# Ingredient Application Author and Title Journal Details Status Link
01 KSM-66 Ashwagandha® Cognitive Function

Choudhary D, Bhattacharyya S, Bose S. Efficacy and safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. J Diet Suppl. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970

Journal of Dietary Supplements published
02 KSM-66 Ashwagandha® Cognitive Function, Energy, and Mood

Kale S, Sarmukkadam S, Swami M, Singh P, Atreya HS. Safety and efficacy of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Cureus. 2024;16(10):e71986. doi:10.7759/cureus.71986

Journal of Psychoactive Drugs published
03 KSM-66 Ashwagandha® Muscle Size, Strength, and Recovery

Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43. doi:10.1186/s12970-015-0104-9

Journal of the International Society of Sports Nutrition published
04 KSM-66 Ashwagandha® Sexual Wellness and Testosterone

Chauhan S, Srivastava MK, Pathak AK. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Health Sci Rep. 2022;5(4):e741. doi:10.1002/hsr2.741

Health Science Reports published
05 KSM-66 Ashwagandha® Sexual Wellness and Testosterone

Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: a pilot study. Evid Based Complement Alternat Med. 2013;2013:571420. doi:10.1155/2013/571420

Evidence-Based Complementary and Alternative Medicine published
06 KSM-66 Ashwagandha® Sleep and Anxiety

Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Cureus. 2019;11(9):e5797. doi:10.7759/cureus.5797

Cureus published
07 KSM-66 Ashwagandha® Sleep and Anxiety

Langade D, Thakare V, Kanchi S, Kelgane S. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: a double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol. 2021;264:113276. doi:10.1016/j.jep.2020.113276 

Journal of Ethnopharmacology published
08 KSM-66 Ashwagandha® Sleep and Anxiety

Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha roo t extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus. 2019;11(12):e6466. doi:10.7759/cureus.6466

Cureus published
09 KSM-66 Ashwagandha® Stress and Anxiety

Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022

Indian Journal of Psychological Medicine published
10 KSM-66 Ashwagandha® Stress and Anxiety

Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. J Evid Based Complementary Altern Med. 2017;22(1):96-106. doi:10.1177/2156587216641830

Journal of Evidence-Based Integrative Medicine published
11 KSM-66 Ashwagandha® Stress and Anxiety

Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus. 2019;11(12):e6466. doi:10.7759/cureus.6466 

Cureus published
12 NEM® eggshell membrane collagen Joint Comfort, Stiffness, and Recovery

Ruff KJ, Morton KM, Duncan SA, Back M. Eggshell membrane (NEM®) reduces exercise-induced joint pain, stiffness and cartilage turnover in healthy men and women: a randomized controlled trial. Int J Phys Med Rehabil. 2024;12:722. doi:10.35248/2329-9096.24.12.722

International Journal of Physical Medicine and Rehabilitation published
13 NEM® eggshell membrane collagen Joint Health

Ruff KJ, DeVore DP, Leu MD, Robinson MA. Eggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clin Interv Aging. 2009;4:235-240.

Clinical Interventions in Aging published
No clinical studies match your search.
Ref #
01
Ingredient
KSM-66 Ashwagandha®
Application
Cognitive Function
Study

Choudhary D, Bhattacharyya S, Bose S. Efficacy and safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. J Diet Suppl. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970

Journal
Journal of Dietary Supplements
Status
published
Ref #
02
Ingredient
KSM-66 Ashwagandha®
Application
Cognitive Function, Energy, and Mood
Study

Kale S, Sarmukkadam S, Swami M, Singh P, Atreya HS. Safety and efficacy of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Cureus. 2024;16(10):e71986. doi:10.7759/cureus.71986

Journal
Journal of Psychoactive Drugs
Status
published
Ref #
03
Ingredient
KSM-66 Ashwagandha®
Application
Muscle Size, Strength, and Recovery
Study

Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43. doi:10.1186/s12970-015-0104-9

Journal
Journal of the International Society of Sports Nutrition
Status
published
Ref #
04
Ingredient
KSM-66 Ashwagandha®
Application
Sexual Wellness and Testosterone
Study

Chauhan S, Srivastava MK, Pathak AK. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Health Sci Rep. 2022;5(4):e741. doi:10.1002/hsr2.741

Journal
Health Science Reports
Status
published
Ref #
05
Ingredient
KSM-66 Ashwagandha®
Application
Sexual Wellness and Testosterone
Study

Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: a pilot study. Evid Based Complement Alternat Med. 2013;2013:571420. doi:10.1155/2013/571420

Journal
Evidence-Based Complementary and Alternative Medicine
Status
published
Ref #
06
Ingredient
KSM-66 Ashwagandha®
Application
Sleep and Anxiety
Study

Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Cureus. 2019;11(9):e5797. doi:10.7759/cureus.5797

Journal
Cureus
Status
published
Ref #
07
Ingredient
KSM-66 Ashwagandha®
Application
Sleep and Anxiety
Study

Langade D, Thakare V, Kanchi S, Kelgane S. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: a double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol. 2021;264:113276. doi:10.1016/j.jep.2020.113276 

Journal
Journal of Ethnopharmacology
Status
published
Ref #
08
Ingredient
KSM-66 Ashwagandha®
Application
Sleep and Anxiety
Study

Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha roo t extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus. 2019;11(12):e6466. doi:10.7759/cureus.6466

Journal
Cureus
Status
published
Ref #
09
Ingredient
KSM-66 Ashwagandha®
Application
Stress and Anxiety
Study

Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022

Journal
Indian Journal of Psychological Medicine
Status
published
Ref #
10
Ingredient
KSM-66 Ashwagandha®
Application
Stress and Anxiety
Study

Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. J Evid Based Complementary Altern Med. 2017;22(1):96-106. doi:10.1177/2156587216641830

Journal
Journal of Evidence-Based Integrative Medicine
Status
published
Ref #
11
Ingredient
KSM-66 Ashwagandha®
Application
Stress and Anxiety
Study

Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus. 2019;11(12):e6466. doi:10.7759/cureus.6466 

Journal
Cureus
Status
published
Ref #
12
Ingredient
NEM® eggshell membrane collagen
Application
Joint Comfort, Stiffness, and Recovery
Study

Ruff KJ, Morton KM, Duncan SA, Back M. Eggshell membrane (NEM®) reduces exercise-induced joint pain, stiffness and cartilage turnover in healthy men and women: a randomized controlled trial. Int J Phys Med Rehabil. 2024;12:722. doi:10.35248/2329-9096.24.12.722

Journal
International Journal of Physical Medicine and Rehabilitation
Status
published
Ref #
13
Ingredient
NEM® eggshell membrane collagen
Application
Joint Health
Study

Ruff KJ, DeVore DP, Leu MD, Robinson MA. Eggshell membrane: a possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. Clin Interv Aging. 2009;4:235-240.

Journal
Clinical Interventions in Aging
Status
published